Author

R. T. McKay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Fischer· 2 shared D. L. Tyrrell· 2 shared E. Arutyunova· 2 shared H. S. Young· 2 shared J. C. Vederas· 2 shared M. B. Khan· 2 shared M. J. Lemieux· 2 shared M. J. van Belkum· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

C. Fischer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

E. Arutyunova, M. B. Khan, C. Fischer, J. Lu, T. Lamer, W. Vuong, M. J. van Belkum, R. T. McKay, D. L. Tyrrell, J. C. Vederas, H. S. Young, M. J. Lemieux

This study characterizes the reversible inhibition of SARS-CoV-2 and SARS-CoV Mpro by GC376, showing nanomolar Ki values and domain swapping in the drug-bound structures.

bioRxiv · Feb 16, 2021Biophysics

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

W. Vuong, M. B. Khan, C. Fischer, E. Arutyunova, T. Lamer, J. Shields, H. A. Saffran, R. T. McKay, M. J. van Belkum, M. Joyce, H. S. Young, D. L. Tyrrell, J. C. Vederas, M. J. Lemieux

This paper shows that feline coronavirus drugs inhibit SARS-CoV-2 main protease and block virus replication in cell culture with low toxicity.

bioRxiv · May 3, 2020Biochemistry