Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice
J. H. Berger, T. R. Matsuura, C. E. Bowman, R. Taing, J. Patel, L. Lai, T. C. Leone, J. D. Reagan, S. M. Haldar, Z. Arany, D. P. Kelly
This study shows that SGLT2 inhibitors improve heart failure in mice independently of their metabolic effects, even when SGLT2 is absent.
bioRxiv · Apr 29, 2024Physiology