Z. Arany

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice

This study shows that SGLT2 inhibitors improve heart failure in mice independently of their metabolic effects, even when SGLT2 is absent.

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

This study shows that the mitochondrial Ca2+ channel MCU supports tumor growth by enabling cell cycle progression and proliferation through mitochondrial Ca2+ uptake, despite unchanged mitochondrial function.

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism

This study shows that dynamic protein deacetylation in Acly-/- MEFs contributes carbons to acetyl-CoA but only transiently supplies about 9% of cellular acetyl-CoA.

CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity

This study uses CRISPR/Cas9 screens to identify RARA and SPNS1 as genetic modifiers of doxorubicin cardiotoxicity, revealing their roles in cell death and drug accumulation.

Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

This paper introduces RIME, a method for rapid in vivo gene editing in adult mouse liver, demonstrating efficient knockout of multiple genes.

Prediction and validation of host cleavage targets of SARS-CoV-2 3C like protease

This study predicts and validates host cleavage targets of SARS-CoV-2 3CL protease using bioinformatics and experimental methods, identifying new targets like Obscurin and linking them to cardiac dysfunction in COVID-19.

Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy

This study identifies metabolic and proteomic defects in human hypertrophic cardiomyopathy, showing depletion of fatty acid derivatives and increased alternate fuel metabolites.

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.