Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolism
F. El Abdellaoui-Soussi, H. B. Durumutla, H. Latimer, A. D. Prabakaran, K. McFarland, K. Miz, K. Piczer, C. Werbrich, M. K. Jain, S. M. Haldar, M. Quattrocelli
This study identifies the cardiomyocyte-specific GR-KLF15 axis as a circadian-regulated regulator of glucose metabolism, showing that timed glucocorticoid administration improves cardiac function in diabetic mice.
bioRxiv · Dec 18, 2023 · PreprintPhysiology