Author

R. Takeda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. H. Gan· 1 shared B. Liu· 1 shared B. Regalado· 1 shared D. Umrani· 1 shared D. W. T. Lim· 1 shared E. T. Ener· 1 shared G. Li· 1 shared G. Wan· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

B. H. Gan

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Author profile →

3 papers

Recent·Most cited

A Unique Promoter Architecture Defines Menin-KMT2A Complex Selectivity

P. R. Freire, B. Regalado, R. Takeda, E. T. Ener, G. Wan, J. A. Cutler, T. Z. Baharav, J. Brown, V. Sharlandjieva, T. Milne, R. A. Irizarry, S. A. Armstrong

The paper identifies a unique promoter architecture that defines Menin-KMT2A complex selectivity and its association with gene regulation and leukemia.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study

B. H. Gan, L. H. Lee, R. Takeda, M. Yasin, V. Teneggi, K. Ethirajulu, P. Yeo, D. Umrani, V. Pendharkar, D. W. T. Lim, G. Li, Q. Lu, Y. Cao, R. Nellore, S. Blanchard, , V. Novotny-Diermayr

This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

A nuclear import pathway exploited by pathogenic noncoding RNAs

J. Ma, S. D. D. Mudiyanselage, W. J. Park, M. Wang, R. Takeda, B. Liu, Y. Wang

The paper identifies a cellular pathway involving Importin alpha-4 and Virp1 that facilitates nuclear import of noncoding RNAs, including viroids and a subviral satellite RNA.

bioRxiv · Dec 2, 2021Plant Biology