Author

L. H. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Daugherty· 1 shared A. P. Lansing· 1 shared B. A. Svajger· 1 shared B. H. Gan· 1 shared C. M. Forster· 1 shared C. Zhang· 1 shared D. A. Howatt· 1 shared D. L. Rateri· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPathology

A. Daugherty

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study

B. H. Gan, L. H. Lee, R. Takeda, M. Yasin, V. Teneggi, K. Ethirajulu, P. Yeo, D. Umrani, V. Pendharkar, D. W. T. Lim, G. Li, Q. Lu, Y. Cao, R. Nellore, S. Blanchard, , V. Novotny-Diermayr

This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

Vascular calcification has a role in acute non-renal phosphate clearance

M. E. Turner, A. P. Lansing, P. S. Jeronimo, L. H. Lee, B. A. Svajger, J. G. Zelt, C. M. Forster, M. P. Petkovich, R. M. Holden, M. A. Adams

This study investigates how vascular calcification affects phosphate handling in rats, finding that calcified arteries preferentially take up phosphate during acute challenges.

bioRxiv · Jul 29, 2020 · PreprintPathology

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

H. Sawada, Y. Katsumata, H. Higashi, C. Zhang, Y. Li, S. Morgan, L. H. Lee, S. A. Singh, J. Z. Chen, D. A. Howatt, J. J. Moorleghen, M. K. Franklin, D. L. Rateri, Y. H. Shen, S. A. LeMaire, , A. Daugherty

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

bioRxiv · Feb 2, 2020Pathology