Author

S. A. Armstrong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

S. W. Lowe· 2 shared A. D. Goldberg· 1 shared A. Deshpande· 1 shared A. Ghosh· 1 shared A. J. Deshpande· 1 shared A. Letai· 1 shared A. Soshnev· 1 shared A. V. Krivtsov· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

S. W. Lowe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Unique Promoter Architecture Defines Menin-KMT2A Complex Selectivity

P. R. Freire, B. Regalado, R. Takeda, E. T. Ener, G. Wan, J. A. Cutler, T. Z. Baharav, J. Brown, V. Sharlandjieva, T. Milne, R. A. Irizarry, S. A. Armstrong

The paper identifies a unique promoter architecture that defines Menin-KMT2A complex selectivity and its association with gene regulation and leukemia.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

bioRxiv · Oct 22, 2021Cancer Biology

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

S. F. Cai, S. H. Chu, A. D. Goldberg, S. Parvin, R. P. Koche, J. L. Glass, E. M. Stein, M. S. Tallman, F. Sen, C. Famulare, M. Cusan, C.-H. Huang, C.-W. Chen, L. Zou, K. B. Cordner, , S. A. Armstrong

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

bioRxiv · May 11, 2020Cancer Biology

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1

K. Barbosa, A. Ghosh, A. Deshpande, B.-R. Chen, Y. Sun, M. Weetall, S. A. Armstrong, S. K. Bohlander, A. J. Deshpande

This study shows that BMI1 is overexpressed in CALM-AF10-positive leukemias and that inhibiting BMI1 with PTC209 or PTC596 reduces leukemia growth and prolongs survival.

bioRxiv · Jan 18, 2019Cancer Biology