Author

S. Blanchard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. A. Q. Al-Khdhairawi· 1 shared A. Leung· 1 shared A. Zubair· 1 shared B. Freeman· 1 shared B. Gordon· 1 shared B. H. Gan· 1 shared C. Wright· 1 shared Christopher G Tate· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. A. Q. Al-Khdhairawi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Positive cooperativity enhances coupling of a second G protein to a GPCR dimer

V. Velazhahan, J. Manning, N. Ma, H. D. Taylor, S. Shrestha, Q. Chen, Y. Ren, S. H. McLaughlin, A. Leung, S. Bar, M. Martin, S. Blanchard, W. B. Asher, J. B. Kelley, H. Dohlman, , Christopher G Tate

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

bioRxiv · Nov 9, 2026 · PreprintBiochemistry

Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study

B. H. Gan, L. H. Lee, R. Takeda, M. Yasin, V. Teneggi, K. Ethirajulu, P. Yeo, D. Umrani, V. Pendharkar, D. W. T. Lim, G. Li, Q. Lu, Y. Cao, R. Nellore, S. Blanchard, , V. Novotny-Diermayr

This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

M. Pan, C. Wright, R. Chapple, A. Zubair, M. Sandhu, J. Batchelder, J. Low, K. Blankenship, L. Wang, B. Gordon, P. Archer, S. W. Brady, S. Natarajan, M. Pozsgai, J. Schuetz, , P. Geeleher

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

bioRxiv · Feb 25, 2021Cancer Biology

Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumor eEF1A antagonist SR-A3

H. Wang, H. Yang, M. Holm, K. Oltion, H. Tom, A. A. Q. Al-Khdhairawi, J.-F. F. Weber, S. Blanchard, D. Ruggero, J. Taunton

This study synthesizes and characterizes SR-A3, a stereoisomer of a natural product, showing enhanced binding kinetics and therapeutic efficacy in a mouse lymphoma model.

bioRxiv · Oct 6, 2020Pharmacology & Toxicology

Differential Profiles of Soluble and Cellular Toll-like Receptors (TLRs) 2 and 4 in Chronic Periodontitis.

H. AlQallaf, Y. Hamada, S. Blanchard, D. Shin, R. Gregory, M. Srinivasan

This study examines salivary soluble TLR-2/4 and epithelial cell-associated TLR-2/4 mRNA levels in periodontitis and gingivitis patients to assess their potential as diagnostic markers.

bioRxiv · Jun 25, 2018Immunology