Author

R. Thamkachy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. A. Jeyaprakash· 2 shared B. Medina-Pritchard· 2 shared J. Rappsilber· 2 shared J. Zou· 2 shared M. A. Abad· 2 shared C. G. Chiodi· 1 shared C. Gallego Paramo· 1 shared D. A. Kelly· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

A. A. Jeyaprakash

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2 papers

Recent·Most cited

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

P. Parashara, B. Medina-Pritchard, M. A. Abad, P. Sotelo-Parrilla, R. Thamkachy, D. Grundei, J. Zou, V. Das, Z. Yan, D. A. Kelly, T. McHugh, J. Rappsilber, A. A. Jeyaprakash

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

bioRxiv · Feb 23, 2024Cell Biology

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

R. Thamkachy, B. Medina-Pritchard, S. H. Park, C. G. Chiodi, J. Zou, M. de la Torre-Barranco, K. Shimanaka, M. A. Abad, C. Gallego Paramo, R. Feederle, E. Ruksenaite, P. Heun, O. R. Davies, J. Rappsilber, D. Schneidman-Duhovny, , A. A. Jeyaprakash

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

bioRxiv · Nov 8, 2021 · PreprintCell Biology