D. Schneidman-Duhovny

This study identifies new DUX4 protein interactions and activation pathways using AP-MS and CL-MS, revealing structural and functional insights into its role in FSHD.

The paper investigates reduced antigenicity of the Omicron variant, showing it evades antibodies and lowers serologic response, with implications for vaccine development.

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

This study uses targeted in situ CLMS and integrative modeling to determine the structures of SARS-CoV-2 Nsp1, Nsp2, and N proteins, revealing key interactions and functional insights.

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

The paper develops a proteomic strategy to analyze antigen-engaged antibody repertoires, revealing high diversity and specificity of camelid heavy-chain antibodies in binding antigens.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

This paper reports the first cryo-EM structure of a bacterial respiratory bc1-cbb3 super-complex and native CIII2 conformers, revealing structural and electronic communication features between complexes.

The paper presents a structural model of full-length human DHDDS using computational and experimental methods, revealing a helix-loop-helix motif in the C-terminal domain and a DHDDS-NgBR heterodimer structure.