A. A. Jeyaprakash

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

Substrate recognition principles for the PP2A-B55 protein phosphatase

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

Estradiol propionate reduction of nuclear size in prostate cancer lines lacking DHRS7suggests DHRS7 absence as a biomarker for the effectiveness of estrogen therapy

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

Oryza genera-specific novel Histone H4 variant predisposes H4 Lysine5 Acetylation marks to modulate salt stress responses

The paper identifies a novel histone H4 variant in Oryza that modulates salt stress responses through chromatin remodeling and acetylation marks.

Direct recruitment of Mis18 to interphase spindle poles promotes CENP-A chromatin assembly

The paper shows that Mis18 directly binds to SPB components to recruit Mis18C, promoting CENP-A chromatin assembly independently of centromeres.

mps1 and mad mutations reduce Cryptococcus neoformans titan cell viability

This study shows that mutations in mps1 and mad genes reduce viability of Cryptococcus neoformans titan cells during reductive division.

Bub1 kinase acts as a signalling hub for the entire Cryptococcus neoformans spindle assembly checkpoint pathway

This study identifies CnBub1 as a multifunctional protein in Cryptococcus neoformans that integrates both Bub1 and Mad3/BubR1 functions in the spindle assembly checkpoint.

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

Molecular Basis for CPC-Sgo1 Interaction: Implications for Centromere Localisation and Function of the CPC

This study identifies the molecular mechanism of CPC-Sgo1 interaction and shows its role in centromere localization and function through structural and functional analyses.

A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.

SUMOylation targets shugoshin to stabilize sister kinetochore biorientation

This study identifies SUMOylation as a mechanism that stabilizes sister kinetochore biorientation by modulating Aurora B kinase and PP2A interactions.

Coordination of NDC80 and Ska complexes at the kinetochore-microtubule interface in human cells

This study investigates the interaction between NDC80 and Ska complexes at the kinetochore-microtubule interface, showing that Hec1 tail phosphorylation affects attachment stability independently of Ska and mapping Ska's location relative to NDC80.

Structural Basis for CAL1-Mediated Centromere Maintenance

This study reveals how Drosophila CAL1 targets CENP-A to centromeres via structural interactions with CENP-A/H4 and CENP-C, bypassing the need for the Mis18 complex.

Direct Nucleosome Binding of Borealin Secures Chromosome Association and Function of the Chromosomal Passenger complex

This study identifies Borealin as the key mediator of Chromosomal Passenger Complex (CPC) chromosome association through direct nucleosome binding, revealing its critical role in chromosome segregation.

Epigenetic inheritance of centromere identity in a heterologous system

This study uses a heterologous system to investigate how dCENP-A is propagated in human cells, identifying key interactions between dCENP-C, CAL1, and dCENP-A for epigenetic centromere inheritance.