Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells
R. Tsuneishi, N. Saku, S. Miyata, P. K. Javaregowda, K. Ite, M. Toyoda, T. Kimura, M. Kuroda, A. Nakazawa, M. Kasahara, H. Nonaka, A. Kamiya, T. Kiyono, J. Yamauchi, A. Umezawa
This study shows that ammonia treatment enriches hepatocyte-like cells derived from human pluripotent stem cells, which can be propagated long-term in vitro while maintaining liver-specific gene expression.
bioRxiv · Mar 20, 2020Cell Biology