M. Kuroda

Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach

This study identifies an inter-organ mechanism of idiopathic pulmonary fibrosis (IPF) using a generative computational approach, revealing a liver-lung crosstalk involving kininogen 1 and bradykinin receptor B1.

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

Parsing the role of NSP1 in SARS-CoV-2 infection

This study investigates the role of SARS-CoV-2 nsp1 in host shutoff and immune evasion, finding it inhibits translation and induces mRNA degradation, and is critical for counteracting the IFN response.

Drug metabolism activity is a Critical Intrinsic Selector for Hepatocytes to elongate cell lifespan by using a cell-killing antibiotic

This study develops a method to expand human hepatocytes in vitro using a cell-killing antibiotic, enabling long-term culture and stable supply for drug research.

An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions.

Identification of a recently dominate sublineage in Salmonella 4,,12:i:- sequence type 34 isolated from food animals in Japan

The paper identifies a new sublineage of Salmonella 4,[5],12:i:-, clade 9-2, which has become dominant in Japanese food animals through genome reductions and antimicrobial resistance.

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

This study shows that ammonia treatment enriches hepatocyte-like cells derived from human pluripotent stem cells, which can be propagated long-term in vitro while maintaining liver-specific gene expression.

Disentangling primer interactions improves SARS-CoV-2 genome sequencing by the ARTIC Network's multiplex PCR

The paper improves SARS-CoV-2 genome sequencing by modifying the ARTIC Network's primer set to reduce primer dimer interactions, enhancing coverage in low viral load samples.

SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates

This study identifies SMAD3 as a key regulator determining conventional DC versus plasmacytoid DC differentiation through distinct gene regulatory mechanisms.

Relationship between ocean area and incidence of anthropogenic debris ingested by longnose lancetfish (Alepisaurus ferox)

This study examines plastic ingestion in longnose lancetfish across different ocean areas, finding higher incidence in Sagami Bay compared to the North Pacific and Indian Ocean.

Salmonella genomic island 3 is an integrative and conjugative element and contributes to copper and arsenic resistance of Salmonella enterica

A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

The paper identifies a novel recombinant porcine EV-G virus with a porcine torovirus PLCP gene replacing viral structural genes, and suggests a potential helper virus role for type 1 recombinant EV-G.