Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction
K. Matsuo, K. Nagata, R. Umeda, T. Shiota, S. Morimoto, N. Suzuki, M. Aoki, H. Okano, M. Nakamori, H. Nishihara
This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.
bioRxiv · Jan 15, 2024 · PreprintCell Biology