K. Matsuo

RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition in vitro

This study shows RNA G-quadruplexes and calcium ions together promote Tau phase transition in vitro under physiological conditions.

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS

The paper investigates the structural polymorphism of RFC1 pentanucleotide repeats associated with CANVAS, showing different G-quadruplex and hairpin structures in DNA and RNA.

Ciliary protein CEP290 regulates focal adhesion via microtubule system in non-ciliated cells

This study identifies a cilia-independent role of CEP290 in non-ciliated cells by regulating microtubule elongation and focal adhesion through its interaction with APC.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

Commensal bacteria promote type I interferon signaling to maintain immune tolerance

This study shows that commensal bacteria promote type I interferon signaling to support immune tolerance by enhancing T regulatory cell function.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

IL-6 blockade suppresses the blood-brain barrier disorder, leading to prevention of onset of NMOSD

The paper shows that IL-6 blockade with satralizumab prevents BBB disruption and lymphocyte migration induced by NMO-IgG in EAE and in vitro BBB models.

Long term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus

This study constructs a live-attenuated SHIV expressing Ag85B and shows it induces strong sterile immunity against pathogenic SHIV in macaques.