N. Suzuki

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids

This study shows that basement membrane extract enhances endochondral ossification in bone marrow-derived mesenchymal stem cell-based cartilage organoids by altering gene expression and pathway activation.

Zinc finger domains bind low-complexity domain polymers

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Quantitative live-cell imaging of secretion activity reveals dynamic immune responses

This paper introduces qLCI-S, a method for quantitative live-cell imaging of secretion activity, enabling single-cell analysis of cytokine secretion and transcriptome profiling of rare cell populations.

Two structurally different oomycete lipophilic MAMPs induce distinctive plant immune responses.

This study identifies two structurally distinct oomycete MAMPs, ceramides and diacylglycerols, that induce different plant immune responses through unique molecular patterns.

Elongation of stigmatic papillae induced by heat stress is associated with disturbance of pollen attachment in Arabidopsis thaliana

This study examines how heat stress affects the morphology of Arabidopsis thaliana reproductive organs, finding that it causes elongation of stigmatic papillae and reduces pollen attachment.