K. Nagata

Roles of C/EBPα, GATA2, TGF-β-signaling, and epigenetic regulation in the expression of basophil-specific protease genes

The paper investigates the transcriptional regulation of basophil-specific protease genes Mcpt8 and Mcpt11, identifying C/EBPα, GATA2, TGF-β signaling, and epigenetic factors as key regulators.

Kaempferol exerts anti-inflammatory effects by accelerating Treg development via AhR-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/RALDH2 gene in dendritic cells

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

This study shows NR4A3 deficiency reduces contact hypersensitivity but worsens psoriasis by altering dendritic cell gene expression.

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Impact of perinatal maternal docosahexaenoic acid-containing phospholipid synthesis on offspring growth and neurological symptoms

This study shows that maternal DHA-PL synthesis during fetal development affects offspring neuropsychiatric outcomes, but not postnatal growth or brain size.

The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling

This study identifies 10-oxo-cis-6,trans-11-octadecadienoic acid as an anti-inflammatory metabolite that suppresses colitis in mice via NRF2 pathway activation and GPCR signaling.

Immunostimulatory effects of Bacillus coagulans SANK70258

This study evaluates the immunomodulating effects of Bacillus coagulans SANK70258, showing it induces high IFN-γ and IgA production compared to other lactic acid bacteria.

Kaempferol suppresses the activation of mast cells by modulating the expression of FcϵRI and SHIP1

This study shows kaempferol suppresses mast cell activation by reducing FcεRI surface expression and increasing SHIP1 levels, independent of transcription and translation.

Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation

This study shows that butyrate and valerate reduce IgE-mediated mast cell activation by enhancing PGE2 release and GPR109A signaling, while niacin also alleviates anaphylaxis through similar mechanisms.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice

This study shows that β-damascone, a rose compound, activates the NRF2 pathway in dendritic cells to reduce immune responses and alleviate contact hypersensitivity in mice.

Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells

This study shows that Lpcat1 deletion causes photoreceptor-specific apoptosis and increased mitochondrial ROS in mice, highlighting its role in lipid metabolism and retinal health.

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.