H. Nishihara

Selectivity and evolution of Aqp10 in solute permeability influenced by pore molecular weight

This study identifies the molecular mechanism behind the reduced solute permeability in Aqp10.2 by analyzing ancestral sequences, structural models, and site-directed mutagenesis.

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Latent taste diversity revealed by a vertebrate-wide catalogue of T1R receptors

The paper identifies five new TAS1R receptors in vertebrates, revealing greater taste receptor diversity than previously thought and their functional roles in ligand recognition.

ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin

The paper identifies NSD2 and ISWI chromatin remodeling complexes as mediators of H3K36me2 enrichment in pericentromeric heterochromatin and shows its presence in early mouse embryos.

The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro

The paper introduces a modular, mass-produced tissue chip platform for barrier tissue models, validated for blood-brain barrier studies and reconfigurable for other applications.