A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma
W.-H. Lin, R. W. Feathers, L. M. Cooper, L. Lewis-Tuffin, J. N. Sarkaria, P. Z. Anastasiadis
This study identifies a Syx-RhoA-Dia1-YAP/TAZ signaling axis that promotes glioblastoma growth, DNA damage, and therapy resistance, suggesting it as a therapeutic target.
bioRxiv · Dec 3, 2021Cancer Biology