J. N. Sarkaria

Cell migration simulator-based biomarkers for glioblastoma

This paper develops a physics-based cell migration simulator to identify physical biomarkers for glioblastoma, linking mechanical parameters to transcriptomic data and drug response.

Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties

This study investigates how glioblastoma cells use hyaluronan to support proliferation and resistance, proposing a combination treatment targeting HA synthesis and degradation.

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

This study shows CHCHD2 promotes glioblastoma cell proliferation, hypoxia-induced invasion, and drug resistance by affecting mitochondrial function and nuclear signaling.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Differential migration mechanics and immune responses of glioblastoma subtypes

This study shows mesenchymal glioblastoma cells migrate faster and generate more traction force than proneural cells, but their immunologically hot environment improves survival despite aggressive growth.

Pericytes and Astrocytes Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model

This study develops an engineered brain perivascular niche model to investigate how pericytes and astrocytes influence GBM tumor cell invasion, proliferation, and therapeutic response.

Complementary role of mathematical modeling in preclinical glioblastoma: differentiating poor drug delivery from drug insensitivity

This paper uses mathematical modeling to differentiate between drug insensitivity and poor drug delivery in glioblastoma PDX models, validated by experimental results.

A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma

This study identifies a Syx-RhoA-Dia1-YAP/TAZ signaling axis that promotes glioblastoma growth, DNA damage, and therapy resistance, suggesting it as a therapeutic target.

The efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

Impact of the radiated brain microenvironment on a panel of human patient-derived xenografts.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

Distinct Long-term Effects of Precision X-Radiation on Reflex Saliva Flow Rate and Tissue Integrity in a Preclinical Model of Chronic Hyposalivation

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

Quantifying glioblastoma drug response dynamics incorporating resistance and blood brain barrier penetrance from experimental data

The paper develops a mathematical model to quantify glioblastoma drug response dynamics, finding that BBB permeability may slightly outweigh drug resistance in therapeutic efficacy.

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

This study uses a 3D hydrogel platform to investigate how extracellular matrix signals affect erlotinib efficacy in patient-derived glioblastoma cells with different EGFR mutations.

Estrogen-related receptor beta activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma

This study shows that ERRβ2 isoform expression, increased by CLK inhibition and ERRβ agonists, reduces GBM cell migration and tumor growth.

Image-based metric of invasiveness predicts response to adjuvant temozolomide for primary glioblastoma

The paper uses image-based metrics to predict TMZ response in GBM patients, finding that less invasive tumors show greater volumetric response and improved survival.

ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach

The paper introduces the ENDURES consortium to study extreme survivors of glioblastoma by integrating clinical data and creating patient-specific tumor models.

Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

This study investigates how different molecular weights of hyaluronic acid in hydrogels affect the invasive behavior of glioblastoma cells.

H3K27me3-mediated silencing of Wilms Tumor 1 supports the proliferation of brain tumor cells harboring the H3.3K27M mutation

This study shows that H3K27me3 silencing of WT1 supports DIPG cell proliferation, despite global H3K27me3 loss due to H3.3K27M mutation.