Cancer BiologybioRxiv
Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma
A. Kapelanski-Lamoureux, Z. Chen, Z.-h. Gao…·R. J. Kaufman
This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.
DOI 10.1016/j.ymthe.2022.10.004