P. Metrakos

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer

This study introduces gravity-based microfiltration to isolate CTC clusters, finding they are prevalent in ovarian and colorectal cancer patients.

Isolation of Extracellular Vesicles from human plasma samples: The importance of controls

The paper evaluates the effectiveness of Thromboplastin D (TP-D) in isolating extracellular vesicles from plasma, finding that it introduces contaminants and is not necessary.

Disruption of integrin alpha-5/beta-1-dependent transforming growth factor beta-1signaling pathway attenuates vessel co-option in colorectal cancer liver metastases

This study shows that inhibiting the integrin alpha-5/beta-1 pathway reduces vessel co-option in colorectal cancer liver metastases by suppressing TGFβ1-driven Ang1 expression.

Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions

The paper investigates apoptosis in hepatocytes during colorectal cancer liver metastasis and finds that cancer cells induce hepatocyte apoptosis to replace them in co-opted lesions.

Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma

This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.