Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma
J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi
This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.
bioRxiv · Dec 14, 2018 · PreprintCancer Biology