Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
I. Zuazo-Gaztelu, D. Lawrence, I. Oikonomidi, S. Marsters, X. Pechuan-Jorge, C. J. Gaspar, D. Kan, E. Segal, K. Clark, M. Beresini, M.-G. Braun, J. Rudolph, Z. Modrusan, M. Choi, W. Sandoval, , A. Ashkenazi
This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.
bioRxiv · Nov 22, 2023Cancer Biology
Y. Carmi, L. Farhat-Younis, M. Na, A. Zarfin, N. Santana-Magal, A. Richter, A. Khateeb, A. Gutwillig, D. Rasoulouniriana, A. Gleiberman, L. Beck, T. Giger, A. Ashkenazi, A. Barzel, P. Rider
This study modifies myeloid cells to elicit tumor-specific cytotoxicity using chimeric receptors that signal through IgM and bind tumor antigens.
bioRxiv · Sep 30, 2023Immunology
F. Amer-Sarsour, D. Falik, Y. Berdichevsky, A. Kordonsky, G. Prag, G. Vatine, A. Ashkenazi
The paper shows polyalanine disease mutations disrupt UBA6-USE1 interactions, impairing ubiquitination and affecting synaptic protein levels in neurons.
bioRxiv · Jun 20, 2022 · PreprintCell Biology
V. Belyy, I. Zuazo-Gaztelu, A. Alamban, A. Ashkenazi, P. Walter
This study reveals that IRE1α activation involves reversible dimer-to-oligomer assembly in response to ER stress, with phosphorylation occurring after oligomerization.
bioRxiv · Sep 29, 2021Biophysics
O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi
The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.
bioRxiv · Sep 10, 2021Cell Biology
A. Le Thomas, E. Ferri, S. Marsters, J. M. Harnoss, Z. Modrusan, W. Li, J. Rudolph, W. Wang, T. D. Wu, P. Walter, A. Ashkenazi
The paper identifies a noncanonical mRNA decay process, RIDDLE, mediated by IRE1α oligomers in cancer cells, which promotes survival by degrading mRNAs without XBP1-like endomotifs.
bioRxiv · Mar 16, 2021 · PreprintCancer Biology
S. D. Carter, N.-H. Tran, A. De Maziere, A. Ashkenazi, J. Klumperman, G. J. Jensen, P. Walter
This study determines the in-situ structure of IRE1 oligomers in ER tubes using cryo-CLEM, revealing helical filaments formed by IRE1 lumenal domain dimers and suggesting positive feedback in IRE1 signaling.
bioRxiv · Feb 24, 2021Cell Biology
M. Levi-Ferber, R. Shalash, A. Le-Thomas, Y. Salzberg, M. Shurgi, A. Ashkenazi, S. Henis-Korenblit
The paper identifies a neuronal circuit regulated by ER stress that suppresses germline differentiation in C. elegans via serotonin signaling and FLP-6 neuropeptide decay.
bioRxiv · Dec 29, 2020Cell Biology
J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi
This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.
bioRxiv · Dec 14, 2018 · PreprintCancer Biology
S. E. Stewart, A. Ashkenazi, A. Williamson, D. C. Rubinsztein, K. Moreau
This study identifies phospholipid flipping as essential for annexin translocation from the inner to outer leaflet of the plasma membrane, with TMEM16F playing a key role.
bioRxiv · Feb 20, 2018Cell Biology