Author

D. Acosta-Alvear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

F. Zappa· 2 shared A. Ashkenazi· 1 shared A. Gogineni· 1 shared A. Heidersbach· 1 shared A. Le Thomas· 1 shared B. Haley· 1 shared D. A. Lawrence· 1 shared D. Kan· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

F. Zappa

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3 papers

Recent·Most cited

The integrated stress response induces a common cell-autonomous death receptor 5-dependent apoptosis switch

N. Lopez Muniozguren, F. Zappa, D. Acosta-Alvear

The paper shows the integrated stress response (ISR) triggers a cell-autonomous apoptosis mechanism via death receptor 5 under overwhelming stress.

bioRxiv · Jul 4, 2022 · PreprintCell Biology

Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering

F. Zappa, N. L. Muniozguren, J. C. Ponce-Rojas, D. Acosta-Alvear

This study shows PKR signaling involves dynamic clusters that buffer downstream signaling, potentially enabling proofreading of the integrated stress response.

bioRxiv · Nov 21, 2021Cell Biology

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintCancer Biology