Author

J. M. Harnoss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

A. Ashkenazi· 3 shared A. Le Thomas· 3 shared D. A. Lawrence· 2 shared J. Rudolph· 2 shared P. Walter· 2 shared S. A. Marsters· 2 shared W. Wang· 2 shared Z. Modrusan· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

A. Ashkenazi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

bioRxiv · Sep 10, 2021Cell Biology

Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survival

A. Le Thomas, E. Ferri, S. Marsters, J. M. Harnoss, Z. Modrusan, W. Li, J. Rudolph, W. Wang, T. D. Wu, P. Walter, A. Ashkenazi

The paper identifies a noncanonical mRNA decay process, RIDDLE, mediated by IRE1α oligomers in cancer cells, which promotes survival by degrading mRNAs without XBP1-like endomotifs.

bioRxiv · Mar 16, 2021 · PreprintCancer Biology

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintCancer Biology