E. Segal

Pangenomes of Human Gut Microbiota Uncover Links Between Genetic Diversity and Stress Response

This study constructs pangenomes of 728 human gut prokaryotic species, revealing genetic diversity linked to stress response, antibiotic resistance, and host characteristics.

Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

The paper introduces StrainPGC and MIDAS v3 to accurately estimate intraspecific microbial gene content variation in metagenomic data, outperforming existing methods and revealing functional diversity in gut microbiomes.

Competitive fungal commensalism mitigates candidiasis pathology

This study identifies a fungal commensal that competes with Candida albicans to reduce its burden and mitigate candidiasis in mice.

Topographical changes in extracellular matrix during skin fibrosis and recovery can be evaluated using automated image analysis algorithms

This study uses automated image analysis to evaluate changes in collagen topography during skin fibrosis and recovery in a Wnt-induced model.

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

In-depth characterization of the serum antibody epitope repertoire in inflammatory bowel disease using phage-displayed immunoprecipitation sequencing

This study identifies distinct antibody epitope repertoires in IBD patients using PhIP-seq, revealing differentially abundant antibodies associated with disease subtypes and features.

Genetic, environmental and intrinsic determinants of the human antibody epitope repertoire

This study uses PhIP-Seq to analyze antibody repertoires in 1,443 individuals, showing genetic and environmental factors influence antibody diversity and phenotype associations.

Antifungal susceptibility testing of Aspergillus niger on silicon microwells by intensity-based reflectometric interference spectroscopy

This paper demonstrates a label-free method using silicon microwells and reflectometric interference spectroscopy to rapidly assess antifungal susceptibility of Aspergillus niger.

Sticky Situations: Bacterial Attachment Deciphered by Interferometry of Silicon Microstructures

This study uses interferometry to analyze bacterial attachment to microstructured surfaces, finding that both bacterial and surface properties influence adhesion and biofilm formation.

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

Molecular anatomy and plasticity of the long noncoding RNA HOTAIR

This study uses atomic force microscopy to visualize the structure and plasticity of the lncRNA HOTAIR in nucleus-like conditions, revealing its interactions with genomic DNA.