Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S. Fiedler, V. Denninger, A. S. Morgunov, A. Ilsley, R. Worth, G. Meisl, C. K. Xu, M. A. Piziorska, F. Ricci, A. Y. Malik, S. R. A. Devenish, M. M. Schneider, V. Kosmoliaptsis, A. Aguzzi, A. Iwasaki, , T. P. J. Knowles
This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.
bioRxiv · Jul 23, 2021 · PreprintBiochemistry