Author

M. M. Schneider

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Assay:proteomics· 6 Organism:human· 4 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. P. J. Knowles· 8 shared G. Meisl· 5 shared C. K. Xu· 4 shared S. R. A. Devenish· 4 shared T. W. Herling· 4 shared V. Kosmoliaptsis· 4 shared A. Aguzzi· 3 shared A. Ilsley· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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8 shared papersBiophysics

T. P. J. Knowles

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Author profile →

10 papers

Recent·Most cited

Thermodynamic profiles for co-translational trigger factor function

T. W. Herling, A. M. E. Cassaignau, A. S. Wentink, Q. A. E. Peter, P. C. Kumar, T. Kartanas, M. M. Schneider, L. D. Cabrita, J. Christodoulou, T. P. J. Knowles

This study identifies the thermodynamic mechanisms underlying trigger factor binding to ribosomes and nascent chains during co-translational protein synthesis.

bioRxiv · Aug 23, 2023 · PreprintBiophysics

Single-molecule digital sizing of proteins in solution

G. Krainer, R. P. B. Jacquat, M. M. Schneider, T. J. Welsh, J. Fan, Q. A. E. Peter, E. A. Andrzejewska, G. Sneideriene, M. A. Czekalska, H. Ausserwoeger, L. Chai, W. E. Arter, K. L. Saar, T. W. Herling, T. M. Franzmann, , T. P. J. Knowles

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

bioRxiv · Jul 12, 2023Biophysics

A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42 Aggregation

K. N. Baumann, M. Sanguanini, O. Rimon, G. Sneideriene, H. Greer, D. Thacker, M. M. Schneider, S. Linse, T. P. J. Knowles, M. Vendruscolo

This study investigates how different lipid membrane models affect Aβ42 aggregation kinetics in vitro, showing inhibition by ER and Golgi membranes.

ACS Chemical Neuroscience · Dec 27, 2022Peer-reviewedBiophysics

Surface interaction patches link non-specific binding and phase separation of antibodies

H. Ausserwöger, G. Krainer, T. J. Welsh, T. Sneideris, M. M. Schneider, G. Invernizzi, T. W. Herling, N. Lorenzen, T. P. J. Knowles

This study links antibody non-specific binding to surface interaction patches and shows how they drive liquid-liquid phase separation under certain conditions.

bioRxiv · Mar 7, 2022 · PreprintBiophysics

Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

V. Denninger, C. K. Xu, G. Meisl, A. S. Morgunov, S. Fiedler, A. Ilsley, M. Emmenegger, A. Y. Malik, M. A. Piziorska, M. M. Schneider, S. R. A. Devenish, V. Kosmoliaptsis, A. Aguzzi, H. Fiegler, T. P. J. Knowles

This study uses microfluidic antibody-affinity profiling to assess cross-reactive antibodies against SARS-CoV-2 in convalescent patients and pre-pandemic sera, finding low affinity and concentration against SARS-CoV-2 spike protein.

bioRxiv · Jul 23, 2021 · PreprintBiophysics

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

S. Fiedler, V. Denninger, A. S. Morgunov, A. Ilsley, R. Worth, G. Meisl, C. K. Xu, M. A. Piziorska, F. Ricci, A. Y. Malik, S. R. A. Devenish, M. M. Schneider, V. Kosmoliaptsis, A. Aguzzi, A. Iwasaki, , T. P. J. Knowles

This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

S. Fiedler, M. A. Piziorska, V. Denninger, A. S. Morgunov, A. Ilsley, A. Y. Malik, M. M. Schneider, S. R. A. Devenish, G. Meisl, A. Aguzzi, H. Fiegler, T. P. J. Knowles

The paper measures how antibody affinity affects the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum using in vitro assays.

bioRxiv · Dec 20, 2020 · PreprintBiochemistry

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles

This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.

bioRxiv · Nov 2, 2020Biophysics

Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum

M. M. Schneider, T. Scheidt, A. J. Priddey, C. K. Xu, M. Hu, S. R. A. Devenish, G. Meisl, C. M. Dobson, V. Kosmoliaptsis, T. P. J. Knowles

This paper develops a microfluidic assay to directly measure antibody affinity and concentration in solution, applied to characterise alloantibody-HLA interactions in transplant patient sera.

bioRxiv · Sep 14, 2020 · PreprintBiophysics

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

J. Pansieri, I. A. Iashchishyn, H. Fakhouri, L. Ostojic, M. Malisauskas, G. Musteikyte, V. Smirnovas, M. M. Schneider, T. Scheidt, C. K. Xu, G. Meisl, T. P. Knowles, E. Gazit, R. Antoine, L. Morozova-Roche

The paper investigates the co-aggregation of S100A9 and Aβ42 amyloids using CDMS, microscopy, and kinetic analysis, revealing templating of S100A9 fibrils on Aβ42 surfaces.

bioRxiv · May 26, 2020Biophysics