S. R. A. Devenish

This study shows that alpha-synuclein oligomers bind more strongly to curved lipid membranes and displace monomeric alpha-synuclein, suggesting a new mechanism for Parkinson's disease toxicity.

The paper links antiviral activity of therapeutic antibodies to their affinity and concentration by comparing them to serological fingerprints in convalescent sera.

This study uses microfluidic antibody-affinity profiling to assess cross-reactive antibodies against SARS-CoV-2 in convalescent patients and pre-pandemic sera, finding low affinity and concentration against SARS-CoV-2 spike protein.

This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.

The paper measures how antibody affinity affects the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum using in vitro assays.

This paper develops a microfluidic assay to directly measure antibody affinity and concentration in solution, applied to characterise alloantibody-HLA interactions in transplant patient sera.