S. Fiedler

Scale-dependent landscape-biodiversity relationships shape multi-taxa diversity in an oil palm monoculture under restoration

The paper investigates how scale-dependent processes affect multi-taxa diversity in oil palm monocultures under restoration using a multi-scale approach.

Alpha-synuclein oligomers displace monomeric alpha-synuclein from lipid membranes

This study shows that alpha-synuclein oligomers bind more strongly to curved lipid membranes and displace monomeric alpha-synuclein, suggesting a new mechanism for Parkinson's disease toxicity.

Protein secretion zones within the Gram-positive cell wall

The paper investigates protein secretion in Gram-positive bacteria, identifying 'secretion zones' where proteins like AmyE are secreted through active transport and passive diffusion.

Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration

The paper links antiviral activity of therapeutic antibodies to their affinity and concentration by comparing them to serological fingerprints in convalescent sera.

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.

Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

This study uses microfluidic antibody-affinity profiling to assess cross-reactive antibodies against SARS-CoV-2 in convalescent patients and pre-pandemic sera, finding low affinity and concentration against SARS-CoV-2 spike protein.

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.

Restoration ecologists might not get what they want: Global change shifts trade-offs among ecosystem functions

The paper develops a simulation model to assess how plant diversity and traits affect ecosystem multifunctionality under current and future climate conditions, finding that trade-offs limit multifunctionality and shift with climate change.

In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

The paper measures how antibody affinity affects the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum using in vitro assays.