Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.
H. S. Segeren, L. M. van Rijnberk, E. Moreno, F. M. Riemers, R. Yuan, R. Wubbolts, A. de Bruin, B. Westendorp
The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.
bioRxiv · Mar 19, 2020Cancer Biology