E. Moreno

Heterotypic competition between cancer cells and hepatocytes generates heterogeneous context-dependent phenotypes

This study characterizes heterotypic competition between cancer cells and hepatocytes, showing varying competitiveness and its impact on metastatic phenotypes.

Characterising the Modulatory Role of Ikebana in Flower-Dependent Cell Competition

This study identifies Ikebana as a modulator of Flower-dependent cell competition, showing its role in regulating loser cell elimination in various contexts.

Longitudinal analysis of Flower-dependent cell competition fitness markers in Drosophila melanogaster

This study examines the dynamics of Flower-dependent cell competition markers in Drosophila over 28 days, revealing that Azot is not required for loser cell elimination and that most apoptotic cells express both Fwe LB and Azot.

Foraging task specialization in honey bees (Apis mellifera): the contribution of floral rewards on the learning performance of pollen and nectar foragers

This study compares learning performance between nectar and pollen foraging honey bees, finding that pollen foragers perform worse with sucrose alone but match nectar foragers when pollen is included as a reward.

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Metabolic snapshot of plasma samples reveals new pathways implicated in SARS-CoV-2 pathogenesis

The paper uses metabolomics to identify metabolic pathways associated with SARS-CoV-2 susceptibility and COVID-19 severity in plasma samples.

Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture

This paper evaluates HCV protease inhibitors as potential SARS-CoV-2 antivirals, finding that simeprevir and grazoprevir synergize with remdesivir to enhance antiviral activity against SARS-CoV-2 in cell culture.

Single-colony sequencing reveals phylosymbiosis, co-phylogeny, and horizontal gene transfer between the cyanobacterium Microcystis and its microbiome

The paper analyzes genomic data from Microcystis colonies and their microbiomes to reveal phylosymbiosis, co-phylogeny, and horizontal gene transfer patterns.

Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside

This paper presents the crystal structure of the 14F7 antibody bound to NeuGc GM3 and shows how membrane composition and curvature influence its binding.

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.

The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.

Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

The paper identifies the largest reservoir of blood cells in adult Drosophila and shows they control survival after bacterial infection by inducing Drosocin expression in surrounding tissues.

INSULIN GROWTH FACTOR I AND ITS RECEPTOR ARE ANTAGONISTIC MODULATORS OF GLUCOSE HANDLING BY ASTROCYTES

The paper shows that unliganded IGF-IR inhibits astrocyte glucose uptake while IGF-I and insulin synergistically enhance it through MAPK/PKD and Rac1/GIPC1 pathways.