R. Yuan

RIP140 regulates HES1 oscillatory expression and mitogenic activity in colon cancer cells

This study shows RIP140 regulates HES1 expression and mitogenic activity in colon cancer cells, with implications for patient survival.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

CXCL4 signaling and gene induction in human monocytes

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.

The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.

Juvenile hormone regulation on the flight capability of Bactrocera dorsalis (Diptera: Tephritidae)

This study investigates how juvenile hormone (JH) regulates flight capability in Bactrocera dorsalis, finding that JH levels correlate with flight duration and distance, and that JH III treatment enhances flight performance.

Ibuprofen-mediated potential inhibition of biofilm development and quorum sensing in Pseudomonas aeruginosa

This study investigates ibuprofen's effect on Pseudomonas aeruginosa biofilm development and quorum sensing, finding concentration-dependent inhibition of virulence factors and gene expression.

Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine

This study demonstrates that GII.17 virus-like particles (VLPs) can be produced and show protective potency against NoV GII.17 infection by blocking saliva histo-blood group antigen binding.

Exogenous putrescine alleviates photoinhibition caused by salt stress through increasing cyclic electron flow in cucumber

This study shows exogenous putrescine increases cyclic electron flow in cucumber under salt stress, improving ATP/NADPH ratios and reducing photoinhibition.