A. de Bruin

Adrenal cortex size, homeostasis and tumorigenesis is regulated by gonadal hormones via androgen receptor/β-catenin signalling crosstalk.

The paper shows that gonadal hormones regulate adrenal cortex size and tumorigenesis via androgen receptor and β-catenin signaling crosstalk, leading to sex-specific outcomes in mice.

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

This study shows that T-cell cholesterol efflux via ABCA1/ABCG1 suppresses apoptosis and senescence, but paradoxically reduces atherosclerosis in middle-aged mice.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53

This study shows that oncogenic RAS increases sensitivity to ATR/CHK1 inhibitors by suppressing P53 transcriptional responses to replication stress.

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

This study shows that acute systemic loss of Mad2 in adult mice causes intestinal atrophy, weight loss, and death within 10 days due to high-grade CIN, with minimal effects on other tissues.

PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis

This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet

This study identifies a spontaneous liver disease in C57BL/6JOlaHsd mice fed a semisynthetic diet, characterized by bimodal liver weight distribution and metabolic abnormalities.

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.

The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice

This study shows that reducing C/EBPβ-LIP expression in mice delays age-related phenotypes and extends lifespan, suggesting therapeutic potential for age-related diseases.