Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses
Bárbara F. Fonseca, Jérôme Wong-Ng, Michael G. Connor, Héloïse Mary, Min Hee Kim, R. Yim, Vincent Bondet, Vincent Michel, Hélène Strick‐Marchand, James P. Di Santo, Darragh Duffy, Mélanie Anne Hamon, Nathalie Sauvonnet, Lisa A. Chakrabarti, Samy Gobaa
This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.
bioRxiv · Mar 31, 2025 · PreprintBioengineering