Michael G. Connor

This study shows that Streptococcus pneumoniae strain TIGR4 activates canonical STAT3 and suppresses non-canonical STAT3 in a burden-dependent manner, while strain 6B ST90 requires higher burden for minimal STAT3 response.

This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.