M. Rak

One-to-one Benefit provided by Antioxidants to cultured skin Fibroblasts from Friedreich Ataxia patients

This study examines antioxidant effects on FRDA fibroblasts, finding variable responses that may hinder clinical conclusions.

Development of selective pyridopyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors

This study develops selective MST3/4 kinase inhibitors and demonstrates their distinct cellular effects compared to MST1/2 inhibition.

Shifting the selectivity of pyridopyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily

This paper develops a selective SIK kinase inhibitor, MR22, by optimizing a pyrido[2,3-d]pyrimidin-7(8H)-one scaffold to eliminate PAK activity, demonstrating its efficacy in ovarian cancer cells.

Structure-based design of selective salt-inducible kinase (SIK) inhibitors

This study designs a selective SIK inhibitor, MRIA9, based on a PAK inhibitor, showing its dual activity and potential for combination therapy in ovarian cancer.

Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency

This study identifies alternative promoters that drive HCMV reactivation from latency, challenging the previous understanding that the MIEP is the primary driver.

Mitochondria Are Physiologically Maintained At Close To 50 °C

The paper measures mitochondrial temperature in situ and finds it can exceed 50°C under physiological conditions, influenced by respiratory chain activity and thermogenic enzymes.