Rachel Cotter

Presynaptic Terminals Dynamically Modulate Spontaneous Release Frequency During Early Synaptic Plasticity Through and Entropic Force Framework

This study shows how presynaptic terminals modulate spontaneous release frequency during early synaptic plasticity using an entropic force framework, revealing changes in synaptic vesicle pool structure and effects of P301L tau.

Central Presynapses Regulate Spontaneous Synaptic Vesicle Exocytosis Rate by Constraining Recycling Pool Density

The paper proposes a framework and model for spontaneous synaptic vesicle exocytosis, showing that presynaptic actin constrains recycling pool density to regulate release rate.

Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.