Michael W. Gramlich

This study shows how presynaptic terminals modulate spontaneous release frequency during early synaptic plasticity using an entropic force framework, revealing changes in synaptic vesicle pool structure and effects of P301L tau.

The paper proposes a framework and model for spontaneous synaptic vesicle exocytosis, showing that presynaptic actin constrains recycling pool density to regulate release rate.

This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.

This study shows that increased extracellular glutamate in tauP301L mice is due to higher VGLUT1 per synaptic vesicle, not increased exocytosis.

This study shows that myosin V regulates the spatial distribution of neurotransmitter release sites in central synapses, affecting both uni-vesicular and multi-vesicular release.