Miranda Nicole Reed

Presynaptic Terminals Dynamically Modulate Spontaneous Release Frequency During Early Synaptic Plasticity Through and Entropic Force Framework

This study shows how presynaptic terminals modulate spontaneous release frequency during early synaptic plasticity using an entropic force framework, revealing changes in synaptic vesicle pool structure and effects of P301L tau.

Prenatal cannabinoid exposure induces sex-specific alterations in placental growth and lipid metabolism gene expression

This study shows that prenatal cannabinoid exposure leads to sex-specific changes in placental growth and lipid metabolism gene expression in rats.

Central Presynapses Regulate Spontaneous Synaptic Vesicle Exocytosis Rate by Constraining Recycling Pool Density

The paper proposes a framework and model for spontaneous synaptic vesicle exocytosis, showing that presynaptic actin constrains recycling pool density to regulate release rate.

Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice

This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.

Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.

rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release

This study shows that increased extracellular glutamate in tauP301L mice is due to higher VGLUT1 per synaptic vesicle, not increased exocytosis.