Author

Jeremiah C. Pfitzer

Auburn UniversityORCID 0000-0002-0785-8312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Michael W. GramlichiD· 3 shared Miranda Nicole ReediD· 3 shared Morgan Hellums· 2 shared David Batista· 1 shared Delaney Gray· 1 shared Emma Redmon· 1 shared Erika Taipala· 1 shared Irfan QureshiiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Michael W. GramlichORCID

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3 papers

Recent·Most cited

Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice

Jeremiah C. Pfitzer, Priyanka D. Pinky, Savannah Perman, Emma Redmon, Luca Cmelak, Vishnu D. Suppiramaniam, Vladimir Coric, Irfan Qureshi, Michael W. Gramlich, Miranda N. Reed

This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.

Journal of Neurochemistry · Aug 30, 2024Peer-reviewedPharmacology & Toxicology

Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release

Rachel Cotter, Morgan Hellums, Delaney Gray, David Batista, Jeremiah C. Pfitzer, Miranda Nicole Reed, Michael W. Gramlich

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.

bioRxiv · Jun 30, 2023 · PreprintNeuroscience

rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release

Erika Taipala, Jeremiah C. Pfitzer, Morgan Hellums, Miranda Nicole Reed, Michael W. Gramlich

This study shows that increased extracellular glutamate in tauP301L mice is due to higher VGLUT1 per synaptic vesicle, not increased exocytosis.

Frontiers in Synaptic Neuroscience · Aug 3, 2022Peer-reviewedNeuroscience