Morgan Hellums

Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.

rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release

This study shows that increased extracellular glutamate in tauP301L mice is due to higher VGLUT1 per synaptic vesicle, not increased exocytosis.