Author

Rachel J Chen

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Assay:ATAC-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ryan D. RisgaardiD· 3 shared André M. M. SousaiD· 2 shared Daifeng WangiD· 2 shared Danielle K. SchmidtiD· 2 shared Jie ShengiD· 2 shared Kalpana Hanthanan ArachchilageiD· 2 shared Sara KnaackiD· 2 shared Shuang LiuiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Ryan D. RisgaardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex

Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, Sara Knaack, Masoumeh Hosseini, Rachel J Chen, Pubudu Kumarage, Danielle K. Schmidt, Xiang Huang, Jie Sheng, Carlos J. Wang, Elisa Giusti, Shuang Liu, Su-Chun Zhang, Daifeng Wang, Anita Bhattacharyya, André M. M. Sousa

This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.

Science · Apr 23, 2026Peer-reviewedNeuroscience

Human-specific features of the cerebellum and ZP2-regulated synapse development

Suel–Kee Kim, Adriana Cherskov, Aastha Sindhwani, Sang-Hun Choi, Hyojin Kim, Mingli Li, Menglei Zhang, Xoel Mato-Blanco, Yuting Liu, Nicola Micali, David Matthew Young, Mark Estación, Yueqi Zhang, Jose Manuel Ruiz-Jiménez, Anandita Nadkarni, , Nenad Šestan

The paper identifies human-specific transcriptomic and regulatory features in the cerebellum, including ZP2's role in synapse development and regulation.

Cell · Mar 1, 2026Peer-reviewedNeuroscience

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex

Yu Gao, Qiping Dong, Kalpana Hanthanan Arachchilage, Ryan D. Risgaard, Moosa Syed, Jie Sheng, Danielle K. Schmidt, Ting Jin, Shuang Liu, Soraya O. Sandoval, Sara Knaack, Magnus T. Eckholm, Rachel J Chen, Yu Guo, Dan Doherty, , André M. M. Sousa

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

Neuron · Aug 1, 2025Peer-reviewedNeuroscience