Author

Yu Guo

University of Wisconsin–MadisonORCID 0000-0002-5869-3335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Sara KnaackiD· 2 shared Xinyu ZhaoiD· 2 shared Yu GaoiD· 2 shared Abbas H. Rizvi· 1 shared André M. M. SousaiD· 1 shared Daifeng WangiD· 1 shared Dan DohertyiD· 1 shared Danielle K. SchmidtiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Sara KnaackORCID

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2 papers

Recent·Most cited

Opposing Experiences Shape Parvalbumin Interneuron Plasticity through Distinct Molecular Programs

Yu Guo, Yu Gao, Sara Knaack, Minjie Shen, Zhiyan Xu, Jiyoun Lee, Yajie Zhang, Paofue Yang, Sabrina X. Huang, Ezra D. Jarzembowski, Drew N Trygstad, Jensen T Weik, Jonathan Le, Keegan A. Schoeller, Elena K. Kandror, , Xinyu Zhao

The paper shows that chronic stress and voluntary running induce distinct molecular programs in parvalbumin interneurons, with stress increasing KAT6A and H3K23 acetylation in the frontal cortex.

bioRxiv · Sep 3, 2026 · PreprintNeuroscience

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex

Yu Gao, Qiping Dong, Kalpana Hanthanan Arachchilage, Ryan D. Risgaard, Moosa Syed, Jie Sheng, Danielle K. Schmidt, Ting Jin, Shuang Liu, Soraya O. Sandoval, Sara Knaack, Magnus T. Eckholm, Rachel J Chen, Yu Guo, Dan Doherty, , André M. M. Sousa

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

Neuron · Aug 1, 2025Peer-reviewedNeuroscience