Author

Rachel Leonard

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Approach:statistical model· 4 Assay:DNA methylation· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Tomasz Jan NowakowskiiD· 4 shared Yuhan HaoiD· 3 shared Clements Evans· 2 shared Emilie M. WigdoriD· 2 shared Frederik Heymann LasseniD· 2 shared Guohua YuaniD· 2 shared Jakob Weiss· 2 shared Joseph J. AsfouriiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Tomasz Jan NowakowskiORCID

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4 papers

Recent·Most cited

A multimodal interrogation of Broca's area in the pediatric and adult human brain

Juan Moriano, Tanzila Mukhtar, Jimmy Tsz Hang Lee, Fani Memi, Jonathan J. Augustin, Rachel Leonard, Joseph J. Asfouri, I-Ling Lu, Clara Siebert, Jennifer Ja-Yoon Choi, Guolong Zuo, Yinshui Chang, Stanislaw Makarchuk, Elina Ziyu Jin, Martin Prete, , Arnold R. Kriegstein

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

bioRxiv · Jul 23, 2026 · PreprintNeuroscience

Molecular dynamics of Brodmann Area 22 in development and autism

Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard, Joseph J. Asfouri, Micheal Griffiths, Clements Evans, Guohua Yuan, Narjes Rohani, Jakob Weiss, Chimmi Dema, Tanzila Mukhtar, Frederik Heymann Lassen, Nicole Schafer, Shan Dong, , Tomasz Jan Nowakowski

The paper identifies transcriptional and epigenomic differences in Brodmann Area 22 in autism, linking them to RFX3-dependent networks and verbal ability.

bioRxiv · Apr 3, 2026 · PreprintNeuroscience

Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism

Guohua Yuan, Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard, Marilyn R. Steyert, Michael Griffiths, Clements Evans, Narjes Rohani, Jakob Weiss, Frederik Heymann Lassen, Nicole Schafer, Shan Dong, Duncan S. Palmer, Stephan Sanders, Tomasz Jan Nowakowski

The paper identifies cell-type-specific molecular and regulatory changes in D1 striosome medium spiny neurons and astrocytes in ASD using single-nucleus multiomic profiling in human putamen.

bioRxiv · Nov 5, 2025 · PreprintNeuroscience

Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders

Kelsey M. Hennick, Yang Sui, Druha Karunakaran, Ally A. Nicolella, Rachel Leonard, Rebecca Meyer‐Schuman, Hanna Berk-Rauch, Tianyun Wang, Aravinda Chakravarti, Huda Yahya Zoghbi, Evan E. Eichler, Tomasz Jan Nowakowski

The paper identifies sex-biased molecular vulnerabilities in the developing human cortex linked to neurodevelopmental disorders by integrating transcriptomic and epigenomic data with mutation analysis.

bioRxiv · Sep 4, 2025 · PreprintNeuroscience