Author

Guohua Yuan

Tsinghua UniversityORCID 0000-0002-4881-0155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Research Focus:gene regulatory network inference· 4 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Clements Evans· 2 shared Emilie M. WigdoriD· 2 shared Frederik Heymann LasseniD· 2 shared Jakob Weiss· 2 shared Narjes RohaniiD· 2 shared Nicole Schafer· 2 shared Qiangqiang ZhangiD· 2 shared Rachel Leonard· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Clements Evans

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular dynamics of Brodmann Area 22 in development and autism

Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard, Joseph J. Asfouri, Micheal Griffiths, Clements Evans, Guohua Yuan, Narjes Rohani, Jakob Weiss, Chimmi Dema, Tanzila Mukhtar, Frederik Heymann Lassen, Nicole Schafer, Shan Dong, , Tomasz Jan Nowakowski

The paper identifies transcriptional and epigenomic differences in Brodmann Area 22 in autism, linking them to RFX3-dependent networks and verbal ability.

bioRxiv · Apr 3, 2026 · PreprintNeuroscience

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation

Qiangqiang Zhang, Guohua Yuan, Elena Albizzati, Jiajun Yang, Zhe Zhao, Xiaojuan Yu, Xuyao Chang, Choong H. Lee, Heng Du, Zhimin Lao, Anjana Krishnamurthy, XP Zhang, Xiaohui Lv, Xing Tang, Shuhan Hu, , Song‐Hai Shi

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

bioRxiv · Dec 27, 2025 · PreprintNeuroscience

Neocortical temporal patterning by a two-layered regulatory network

Guohua Yuan, Zhe Zhao, Xiaoxiang Dong, Wang Xu-wen, Qiangqiang Zhang, Xiaojuan Yu, Ming Zhu, Jiawei Yu, Di Zhang, Nantao Zhang, Zhiheng Xu, Lei Dai, Yang‐Yu Liu, Song‐Hai Shi, Yinqing Li

The paper identifies a two-layered regulatory network governing temporal patterning in neocortical development through single-cell multi-omics analysis.

bioRxiv · Dec 22, 2025 · PreprintNeuroscience

Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism

Guohua Yuan, Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard, Marilyn R. Steyert, Michael Griffiths, Clements Evans, Narjes Rohani, Jakob Weiss, Frederik Heymann Lassen, Nicole Schafer, Shan Dong, Duncan S. Palmer, Stephan Sanders, Tomasz Jan Nowakowski

The paper identifies cell-type-specific molecular and regulatory changes in D1 striosome medium spiny neurons and astrocytes in ASD using single-nucleus multiomic profiling in human putamen.

bioRxiv · Nov 5, 2025 · PreprintNeuroscience

Estrus-Tracking Cortical Neurons Integrate Social cues and Reproductive states to Adaptively Control Sexually Dimorphic Sociosexual Behaviors

Yuping Wang, Xinli Song, Xiangmao Chen, Ying Zhou, Jihao Ma, Fang Zhang, Liqiang Wei, Guoxu Qi, Nakul Yadav, Benjie Miao, Yiming Yan, Guohua Yuan, Da Mi, Priyamvada Rajasethupathy, Inés Ibáñez-Tallon, , Kun Li

The paper identifies mPFCCacna1h+ neurons that integrate hormonal states and social cues to control sexually dimorphic sociosexual behaviors in females and males.

bioRxiv · Aug 30, 2024 · PreprintNeuroscience