Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration
Anjali P. Patni, Rubul Mout, Rachel Moore, Ammar Alghadeer, George Q. Daley, David A. Baker, Julie Mathieu, Hannele Ruohola‐Baker
The paper demonstrates that a designed soluble Notch agonist can drive iAM maturation without odontoblast contact, revealing DLX3's role in ameloblast-specific Enamelin and MMP20 expression.
bioRxiv · Apr 3, 2025 · PreprintDevelopmental Biology