George Q. Daley

This paper develops a live-cell transcriptomics method using engineered virus-like particles to capture dynamic gene expression without destroying cells.

This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.

This paper identifies small-molecule modulators that enhance the generation of functional cytotoxic T cells from hiPSCs, increasing CTL production up to 2000-fold.

This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.

The paper demonstrates that a designed soluble Notch agonist can drive iAM maturation without odontoblast contact, revealing DLX3's role in ameloblast-specific Enamelin and MMP20 expression.

The paper identifies ZCCHC6 and DIS3L2 as key regulators of RNA decay during terminal erythropoiesis, showing their role in post-transcriptional globin switching and {gamma}-globin stabilization.

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

The paper shows that extracellular vesicles from healthy cells can reverse GABAergic synaptic deficits in Huntington's disease neurons by modulating miRNA content.

The paper identifies downregulation of the CCR1 immune pathway in SF3B1-mutated cancers and links it to potential therapeutic targets.

The paper identifies a Lin28b-let-7-PRC1 axis that regulates hematopoietic maturation across development, with Cbx2 playing a key role in controlling developmental timing of hematopoietic transcription factors.

The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.

This study uses scRNA-Seq and scATAC-Seq to show that human reprogramming occurs through asynchronous, diverse trajectories with distinct regulatory networks.