Rubul Mout

This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.

The paper demonstrates that a designed soluble Notch agonist can drive iAM maturation without odontoblast contact, revealing DLX3's role in ameloblast-specific Enamelin and MMP20 expression.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.